The Haldane rule (Haldane, 1935) predicts that one-third of cases of a genetic lethal X-linked recessive will be the consequence of new mutation.Haldane (1956) further suggested that the mutation rate for Duchenne muscular dystrophy might be higher in males. Such would result in a lower proportion of cases being new mutants. Caskey et al. (1980) concluded that in their series cases resulting ... Ground Rules for the Power Level Discussion Thread As always, please follow the guidelines set by the Forum Rules that apply across the board. It's important that discussions from a current chapter are spoiler tagged until 24h have passed from an english release. For the sake of... One Piece English Dubbed Gogoanime; Watch One Piece English Dub; One Piece Episode 1 Gogoanime; One Piece episode 827 english subbed watch online free download hd live streaming by Crunchyroll, Funimation One Piece is one series with a widespread popularity, and has a very dedicated fan base. Events Pre-1600. 312 – Constantine the Great enters Rome after his victory at the Battle of the Milvian Bridge, stages a grand adventus in the city, and is met with popular jubilation. Maxentius' body is fished out of the Tiber and beheaded.; 437 – Valentinian III, Western Roman Emperor, marries Licinia Eudoxia, daughter of his cousin Theodosius II, Eastern Roman Emperor in Constantinople ...
2021.12.05 20:40 Remarkable_Scar_8647 Who would win? Old White Beard v Kaido
2021.12.05 20:40 LetMeOmixam In your opinion, what's the most frustrating ability in the game?
I'll start with Banshee's Wail. That's some bs right there man. From full health to death saving throw. A few months my DM almost TPK'd us by having a Banshee appear in front of the party and use it. If not for the cleric making the check and then using Mass Healing Word that would a been a campaign ender.
Wail (1/Day). The banshee releases a mournful wail, provided that she isn’t in sunlight. This wail has no effect on constructs and undead. All other creatures within 30 feet of her that can hear her must make a DC 13 Constitution saving throw. On a failure, a creature drops to 0 hit points. On a success, a creature takes 10 (3d6) psychic damage.
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2021.12.05 20:40 Knotall My 3 month old sweet baby girl.
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2021.12.05 20:40 jackrainbow Found out boss is slandering my name to other coworkers.
I recently found out my boss has been telling other coworkers my personal business, telling them false information about a previous business of mine, and questioning/laughing about my request for a raise. I found all this out after I handed in my notice and they have been begging me to stay and offered me a pay raise plus benefits which I have declined. Is there any legal action I can take here?
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2021.12.05 20:40 SeaworthinessSome647 Zekrom adding 10 6455 0110 5484
2021.12.05 20:40 GNGVir Seven Outpost I Location Fortnite
2021.12.05 20:40 WollyTwins [Twins] When you finally get the call
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2021.12.05 20:40 Hystim Why do you use tack shooter?
I liked tack shooter in BTD 6 after I found out how good bottom path was especially with top path village. I was planning on using tack or ninja with sub and alch, which are two other towers I like. What is your reason for using tack?
submitted by Hystim to battles2 [link] [comments]
2021.12.05 20:40 cheezeball73 My first attempt at Challah and by far the best bread I've ever baked.
2021.12.05 20:40 LiseEclaire [Leveling up the World] - Adventure Arc - Chapter 338
Out there - Patreon (for all those curious or wanting to support :))
Adventure Arc - Arc 2
Previously on Leveling up the World…
The shock hadn’t come right away. Too many unusual things had occurred after Dallion’s first battle for him to react adequately. Chief among them were the rectangles appearing in the real world. That was absolutely not supposed to happen. To make it even more ominous, to Dallion’s alarm—or relief depending on the point of view—no one else had seen them, not even his echoes or familiars. As far as they were concerned, the only difference was a new stat and achievement appearing within the rooms of his realm. The unusualness didn’t end there.
As Nil had pointed out, getting an achievement while in the real world was unheard of. Even when establishing new domains, one had to enter them to be made aware of their existence, as well as the peculiar set of rules that came with them. Dallion didn’t have the courage to share that this wasn’t the first time he had seen rectangles in the real world, instead moving the conversation on the next abnormal element—the new attribute itself.
The name sounded cheesy, almost comical. What it allowed Dallion to do, though, was far from it. Up to this point, he had often wondered how come he was able to converse with guardians on occasions, while others couldn’t. The reason was the inkling of the empathy stat he had. Even having a fraction was enough for awakened creatures and guardians to treat him differently, especially dryads. That was how the armadil shield had become aware of his presence in the first place, as well as the reason it had reached out to Dallion. This also explained the Green Moon’s interest. Now that the stat was fully developed, the veil had been lifted allowing Dallion to read about it in the ring library scrolls, as well as have proper conversations with Nil and his other echoes about it—as the limitations had been lifted from him, they were lifted from them as well.
All that, however, paled in comparison to the actual effects that the new stat provided. From the moment the rectangle had appeared in front of Dallion in the middle of the arena, he had gained the ability to talk to any item and area guardian, and all of them could talk back.
Don’t sweat it, the guardian of the inn’s room said. Most of us like you, so it won’t be a problem. I’ll make sure no one here gives you any trouble.
“Thanks,” Dalion said, lying on the bed, eyes closed. He was extremely thankful that he had been cleaning his room regularly for the past few weeks. If he had been negligent in that regard, there was no telling what could have occurred. Items getting misplaced was one of the possibilities. In any event, Dallion would have gotten an earful.
I know this might be a bit overwhelming, dear boy, but consider the gift that you have been granted, Nil said. This is the stat that has been truly lost to humanity. Throughout the entire empire, there’s no one who has it. Mages are more popular, and those are one in a million.
Easy for you to say. You don’t get objects talking to you every step you make.
That’s most likely the initial burst. It’ll pass once you get used to the stat, and the world gets used to you.
That didn’t sound too reassuring.
You really don’t know how to look on the positive side even when you win, do you? The old echo sighed. Once you get this under control, you get to talk to any guardian pretty much about anything without even having to enter an awakened realm. That allows you to learn pretty much to learn about every person there is. Other than ancient artifacts, you can have items tell you things about their owners you’d otherwise have to spend months or years learning.
Dallion was just about to comment on how absurd he found the idea, when it suddenly hit him. The way things were, he actually did have the power to get information from items about their owners. As he had seen, people—even awakened—didn’t treat items too well, especially those they weren’t linked with. But even in the cases when there was a strong bond between a person and their item guardians, he also had quite advanced music skills; and from what he had seen, there was no reason music wouldn’t affect guardians the same way it affected people.
Will I be able to do that in the world item? Dallion asked.
I couldn’t say, the echo hesitated.
It was a difficult question. On the one hand, the item’s realm was considered a world. However, it was also clearly a realm, making it less likely that the items within would be treated as actual items. Also, as it turned out, Dallion’s new ability didn’t extend to cracklings. Nox and Lux continued to converse using their standard means, only being understood thanks to the link Dallion had established with them. Normal crackling remained unintelligible.
But the possibility does exist, Nil continued. Otherwise, the real would simply have been described as a giant sphere item. But even if that doesn’t turn out to be the case, you’ll have a clear advantage when dealing with the guardians. There’s every chance that they don’t attack you.
There was a certain logic to that. Of course, it meant that Dallion had to sneak back into the realm on his own. Even if the guardians were willing to let him pass their domains unharmed, they weren’t going to hesitate attacking an expedition, especially if it was set on leveling up the realm.
Everything considered, Dallion decided to visit the guild during the night. As a regular guild member, he had the right to do so. Before that, he had to rest a bit.
Sleep came fast. The morning’s leveling up combined with the arena fight had exhausted him to the extreme. As he dozed off, Dallion wondered how Mord was doing. His self-proclaimed rival didn’t seem particularly happy to have lost. Dallion had sensed enough anger and disappointment to sink a ship, and yet the guy had managed to keep it inside. Dallion pitied the rest of the Flameforger’s opponents.
When Dallion opened his eyes again, he was woken up by a knock on the door.
Who’s that at this time? He wondered.
Your gorgon friend, the door guardian replied.
The response made Dallion almost jump from his bed. He wasn’t used to having objects reply to his rhetorical questions. As Nil had said, Dallion was going to have to relearn now to talk using his new skills. Up to now, it was hardly a problem—only the small number of inhabitants in his realm replied to his thoughts. With the new skill at his disposal, that had changed. From now on, he had to develop two ways of mental thought: one for communication with guardians and one for his own personal thoughts. Either that, or he was going to start relying on blocker rings a lot more.
Straightening his clothes as best he could, Dallion opened the door. Upon seeing Eury, he expected a kiss, or at least a hug, but got neither.
“Hi,” the gorgon walked in.
“Hi,” Dallion said, trying best to hide his disappointment. “Long stroll after work?” he put on a fake smile.
“Nope, I actually came to see you.” Eury made her way through the room. “Especially the remains of your boots.” She picked the right one up. The damage was extensive. Then again, considering what Dallion had pulled off, it was a miracle that the entire boot hadn’t burst to shreds.
“I saw you at the arena,” Dallion approached the topic.
“I know.” The gorgon replied as a third of the snakes on her head examined the boot, the rest focusing on the room and Dallion.
“You were with the overseer.”
“And you were reckless as usual.” While Dallion could hear the note of concern and anger in her voice, his music skills didn’t let him catch any additional emotions. She had to be wearing a blocker. “If you want to use that trick again, I’ll need to make you a new pair. And that won’t happen until after the festival.”
“I won’t be using it again.” Dallion moved closer to her. “It was just this once.”
“Good.” Eury put the boot back on the ground. “I’ll take this and fix it up for tomorrow.”
“Pretty much.” There was a long, awkward pause. “Look, I know what you mean, but right now isn’t the best time. I have things I need to focus on. You know how it is.”
Dallion didn’t, but he had seen enough excuses in high school to know where this was going. Part of him could already feel the pain, while another refused to accept it, hoping that he was misinterpreting things.
“That’s not actually why I’m here, though,” she said. “Your new sword. Where did you get it from?”
“An acquaintance gave it to me,” Dallion replied. “It’s on loan until I drop out of the tournament,” he lied. “It took me a few days to get used to it. I passed by your workshop to tell you about it, but you weren’t there.”
“You must have caught me at a moment while I was out.”
If there was a moment at which Dallion had questions for an item guardian, that was now. Unfortunately for him, the blocking item Euryale was using prevented him from doing so.
“Things will be different once the festival is over. So, I’ll fix this for you and have it ready for tomorrow’s fight. Will you be using Lux then?”
“Only if I have to.”
“Try to keep it down. The overseer doesn’t like the flash much.”
There were a dozen things Dallion should have said. Questions about what had happened between them, things he wanted to discuss, even laughs to have. However, he felt that none of that would work if he tried. The thought of splitting and having a conversation with her came to mind. At least that way he’d get the important answer. Possibly it would have worked, but it wasn’t something he wanted to try.
“I’ll do my best. Anything else?” Dallion asked with an icy note.
“No, that’s it.”
“See you before the fight tomorrow, then.” Dallion took a step to the side, leaving a clear path to the door.
There was no doubt in his mind that the gorgon got the hint. The snakes on her head moved about, slightly more agitated than usual, then returned to their standard semi-motionless state. Holding the damaged holster boot, Eury took a step towards the door.
“You’re still keeping it,” she said, a cluster of snakes, turning to the stone orchid. “It looks better than before.”
“I’m doing my best,” Dallion said, unsure how to react.
“I know.” The gorgon smiled, then left the room. For close to a minute Dallion stood there, trying to figure out what just had happened. This was definitely not a conversation he wanted to have, especially now.
Maybe I’m just overreacting, he thought, waiting for any of his echoes to correct him. None did. Well, it was fun while it lasted, he added, mostly for himself.
Even after all the flaws he had dealt with while leveling up, there remained things he still had difficulty coping with. This was one of them, especially since Dallion honestly thought that there was more than chemistry between him and Eury.
No advice from you, shield?
You can try to change her mind, but I doubt you’ll get anywhere before the festival, the dryad guardian replied. And once it’s over, it’ll likely be too late.
I see… In that case, the best solution for tonight was to continue forward and occupy his mind with other things. We’re heading back into the sword realm.
Maybe now’s not the right time to make rash decisions, Nil said. I’d suggest sleeping it off, or better spend some time downstairs. Hannah will make sure that everyone learns about you passing the first round and—
We’re going to the guildhall, Dallion cut him short as he made his way to the window. There’s still a reason for the Star to want to be added on the expedition so badly, and I don’t think the ring key is it. Whatever’s hiding there, I plan on getting it first!
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2021.12.05 20:40 Isoredtaw Found this in a river bed, anybody know what this might be?
2021.12.05 20:40 KozzyD Inconsistent lines
Okay so I'm going to try to put as much detail down as this is frustrating.
I have a ender 5 plus Btt 1.4 turbo Tft35 screen And a few extra bits
When I got my printer I upgraded my extruder to a dual metal one (you know the cheap red ones) but very quickly the nut from the gear kept coming loose causing fails. But a few days ago I had a failed print with a new extruder gear with a tighter lug and it stopped about 2 layers in (about 20 minutes into a 8 hour print) but wirdly now after I have changed and cleaned everything apart from the hotend I noticed the skirt when printing keeps failing in the same spot and the filament drags up and onto the nozzle for a bit then continues on but the stranges thing is now nothing is sticking to my bed. I have cleaned it with 99% ISO yet nothing.
FYI I have cleaned the hotend and I can see perfectly though it when everything is apart there is no blockage but when filament is being pushed out it does curl quickly up towards the nozzle. I don't know weather I should get a new hotend or new bed at this stage.
Everything I have done: Changed nozzle 3 times Cleaned hotend with cleaning filament & cold pulls Changed extruder and cleaned gears Changed ptfe tubes Changed quick connectors Done e step calibrations
submitted by KozzyD to FixMyPrint [link] [comments]
2021.12.05 20:40 glamrockbonnie [ oc / fanart ] skully icons, free 2 use with credit :]
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2021.12.05 20:40 HomicideRHCP The heretic will not take my Christmas cheer
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2021.12.05 20:40 Bebebewke What a thing you'd be fastest in?
2021.12.05 20:40 ddh4587 Mega Steelix 3437 1090 5438
2021.12.05 20:40 Uplift3r91 Happy holidays, fellow krewsaders!
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2021.12.05 20:40 Doctoma I need some slow Jerry ballads. Just that kind of night.
It's been a pretty rough day on my end and I've mostly kept things together by playing Dead music every moment I can. Jerry's soulful voice and guitar help make sense of feelings I just don't know how to deal with. My main rotation has been Roses, To Lay Me Down and Ripple off Reckoning, Brokedown Palace off Dead Set, Row Jimmy from DP 29, 10/1/94 So Many Roads, 7/18/76 Mississippi Half-Step, Amazing Grace from the Pizza Tapes and the 6/8/76 Looks Like Rain because Bobby can really get me too.
What's your favourite heart-tugging Jerry performance?
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2021.12.05 20:40 TheWeebler Numbers are not just numbers in spanish?? Many of my friends speak Spanish fluently and do not understand this either. Someone please explain. Is this only specific to certain countries? (An example below)
My teacher a few semesters ago gave me this assignment and I still do not understand. I got a 3/10 on it and he never told me the correct answers or explained.
Fill in the blank with the correct number of (written out in Spanish) for the number in parentheses, as in the example below.
Esta noche voy a tomar una sopa que es trescientas ciencuenta (350) calorías.
Remember that numbers in the 200-900 range show agreement with the following noun.
2021.12.05 20:40 mulherfitness Receita de Salada de Couve-Flor Temperada com Romã
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2021.12.05 20:40 PlatformKnuckles Good time for 4.4?
Almost the end of the year. Maybe a good time to update it?
1315 commits to master since this release
Distros ship with 4.3 in their repos which forces, me at least, to always get the git version since my settings are incompatible with 4.3. Though it's not a big issue for me, but it should be updated at some point I think.
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2021.12.05 20:40 NaggerGuy Guess the signature
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2021.12.05 20:40 Tightgirl9428 First impression? F24
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2021.12.05 20:40 username-is-taken98 Guys I know I'm new to this but I think I found a cheat code, but I need to know if I'm actually doing good or just hurting my tulpa. Please help I'm not entirely sure what I'm doing is good.
Basically, I built a tulpa using my intrusive thoughts and by doing so I was able to do it in a single day as an absolute beginner.
My thought process was basically " I know how most say we're supposed to shield undeveloped tulpas from intrusive thoughts, but what if instead we used intrusive thoughts as the basis for our tulpas instead?"
Now don't misunderstand me, by intrusive thoughts I'm not necessarely talking about negative thoughts, the last thing I need is an extra voice telling me about how worthless I may or may not be. By intrusive thoughts I am referring to any thought that conflicts with my personality.
While I was reading up on guides I often found many kept repeating that "tulpa's thoughts should feel alien to the host" so my logic was that I could instead take thoughts that are already alien to me and give them to my tulpa so that they would be independent from the start, and for me it worked like a magic bullet.
Let me go into a bit more detail about my situation. I am a guy with many flaws, most of them caused by my psyche, so the idea of having a friend inside my head that could know me like no one does and maybe help me understand parts of myself is what drew me to the community and the practice. It's not like I want a tulpa just so she can be my therapist but in my mind I justified it like "you help me sort my shit out, I help you obtain what makes you happy whatever it may be. You have access to my subconcious, I have access to a phisical body, we can help each other out and improve our lives togheter". I'm such a hopeless romantic, I know, but this helped me outline the foundations of my tulpa's personality. Now, my intrusive thoughts, some are the typical self deprecating kind and I usually just push those away, but most are just common sense and I used those as my building blocks. For a more practical example, when I'm procastinating and just feel like sleeping I keep to myself the thoughts that are in line with my personality (I'm so tired, I cant' do this anymore), filter out any self sabotaging idea ( there you go, sleeping again, this is why you never get anything done, you'll keep failing at everything like this) and give the remaining logical stuff to my tulpa (you know you're not tired, get up and fix your issues instead of moping around so that you'll feel better) so that when I'm parroting I'm not feeding my words to my tulpa but rather words that I already know I'm not my own. Of course I'm adding some alterations here and there to help my tulpa learn to think differently than me rather than just become a clone of my inner voice but this way I'm sure that it's always her words and never my own.
By doing this I went from talking to myself whole forcing myself to believe for 2 weeks to having a vocal tulpa in a single day.
Now I'm not stupid. I know that most guides say to do what feels right but I'm not just ignoring what most guides told me, I'm explicitly going against what's been common sense in the community since long before I even knew what a tulpa was, so in a way I m stuck between the undeniable results and the fear that I'm actually hurting this precious life that now lives in my head.
What worries me most is two things. First off is the common advice not to give a tulpa negative traits on purpose. Now nothing that I did was done on purpose or bad faith but I can't deny that my tulpa is way more confrontational and aggressive than I anticipated in the blueprint I made for her. Now I was ready for her to be different than I imagined and she's not a bad person or like the evil tulpas of creepypastas in any way but I'm too inexperienced to say wethere this should be considered deviation or I'm forcing this onto her.
My second issue is that while she is amazing and feels almost sentient when she elaborates on the intrusive thoughts I give her she's almost uncapable of expressing herself about anything else. She doesn't seem to have opinions on anything besides me, and the best that I could get out of her about herself when I asked what she likes she sort of replied that "she likes being used to mitigate my inner conflicts and spur me on because it makes me pay attention to her". I can't say I'm too happy to hear such a self erasing response.
I know she is sentient and independent, I just feel it inside, plus she l's like 12 hours old, it may just be me being too inexperienced to let her express herself or she might even just be shy about these things, but I can't help thinking that since she was constructed like this I might be stunting her growth.
This is everything I can think to help get the situation across, ultimately my only goal is to help my tulpa being as healthy as she can so please, any help or criticism is more than welcome.
Thanks in advance everyone
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2021.12.05 20:40 goyardspaceranger361 uzi talking to a gc
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